The Mrksich Group
At the Interface of Organic Chemistry, Materials Science, and Biology
About Our Group
The Mrksich Group uses the tools of organic chemistry, materials science and biochemistry to address important challenges in and at the intersection of chemistry and biology.
In one program, we emphasize the development of methods to perform high throughput experiments by combining engineered surfaces and mass spectrometry in a technique known as SAMDI-MS. This method has been used extensively to profile enzymatic activity both in situ and in complex lysates while permitting the analysis of tens of thousands of experiments in a day. We have also pioneered the development of Megamolecules – a new way to engineer protein-based molecules with much greater control over their structure and complexity than with traditional techniques. With this approach, we can build structures composed of more than twenty protein domains, with branched, cyclic and dendritic architectures, and with molecular weights in excess of a million Daltons, for a broad range of basic and applied applications.
Our group utilizes the inert, ordered structure of self-assembled monolayers with MALDI-MS (SAMDI) to profile biological and chemical reactions in a label-free, high-throughput manner.
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