The Mrksich Group

At the Interface of Organic Chemistry, Materials Science, and Biology

Justin and Tsatsral’s Article Published in JACS!

Congrats to Justin and former lab technician Tsatsral for having their article "Design and Synthesis of Megamolecule Mimics of a Therapeutic Antibody" accepted into the Journal of the American Chemical Society! Read the full article here!

Eric and Elamar’s Article Featured on Cover of Small

Dr. Eric Berns’s and Elamar Hakim Moully’s recent article titled  “Temporal Sampling of Enzymes from Live Cells by Localized Electroporation and Quantification of Activity by SAMDI Mass Spectrometry”, published by Small, was featured on the insider cover! To view the...

Kevin Metcalf’s Article Published in Biomolecules!

Congratulations to Postdoc and Alumnus, Kevin Metcalf, and all collaborators for publishing their paper entitled “Role of Lipopolysaccharide in Protecting OmpT from Autoproteolysis during In Vitro Refolding” in Biomolecules! Read the full article here!

Yael Joins the Search Committee for OIDI CDO

Our Business Administrator, Yael Mayer, joins the committee dedicated to searching for and identifying a new Chief Diversity Officer (CDO) to lead the Office of Institutional Diversity and Inclusion (OIDI)! Click here to read more on the committee in Northwestern Now.

Alison’s Article Published in PNAS

Congrats to Alison for publishing her paper entitled "A High-Throughput Photocapture Approach for Reaction Discovery" in Proceedings of the National Academy of Sciences! Read the full article here!

About Our Group

The Mrksich Group uses the tools of organic chemistry, materials science and biochemistry to address important challenges in and at the intersection of chemistry and biology.

In one program, we emphasize the development of methods to perform high throughput experiments by combining engineered surfaces and mass spectrometry in a technique known as SAMDI-MS. This method has been used extensively to profile enzymatic activity both in situ and in complex lysates while permitting the analysis of tens of thousands of experiments in a day. We have also pioneered the development of Megamolecules – a new way to engineer protein-based molecules with much greater control over their structure and complexity than with traditional techniques. With this approach, we can build structures composed of more than twenty protein domains, with branched, cyclic and dendritic architectures, and with molecular weights in excess of a million Daltons, for a broad range of basic and applied applications.


Surface Chemistry, High-Throughput Experiments, and Protein Engineering

High-Throughput Experiments

Our group utilizes the inert, ordered structure of self-assembled monolayers with MALDI-MS (SAMDI) to profile biological and chemical reactions in a label-free, high-throughput manner.


Our group developed a platform for assembling large (~MDa), modular, homogeneous protein structures for therapuetic and diagnostic use. 

Surface Chemistry and Cellular Control

Our group uses microcontact printing, dynamic photoactivation, and other methods to engineer substrates that control cellular adhesion and behavior.

Funding Acknowledgements

Interested in Joining or Have Questions?

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