High-Throughput Experiments

SAMDI-MS (Self-Assembled Monolayers for Matrix-Assisted Desorption/Ionization Mass Spectrometry) technology was first described by Milan in 2002 as a solution to the challenges and pitfalls of label-dependent biochemical assays. He found that self-assembled monolayers (SAMs) could be analyzed by MALDI mass spectrometry, a key discovery that provided the foundation for the label-free and high-throughput SAMDI-MS assay. By covalently immobilizing analytes to an engineered surface, the technique allows for experimental throughput exceeding thousands of reactions per day. Today, our group continues to develop and evolve this platform to enable reproducible and quantitative assays at every stage of the experimental workflow. Click below to learn more about the various applications of SAMDI our group has developed.