The Mrksich Group

At the Interface of Organic Chemistry, Materials Science, and Biology

Congratulations to Tori!

A huge congratulations from the Mrksich Group to Tori Seto for defending her PhD thesis! We wish you the best on your future endeavors!

Congratulations to Zhaoyi Gu!

A huge congratulations to Zhaoyi for defending her PhD thesis and we wish her all the best in her future at Abbvie!

Two Perspectives Introduce Structural Nanomedicine

With coauthors Professors Mirkin, Langer and Artzi, Milan discusses the importance of bringing structural control to multi-functional nanomedicines, and the opportunity offered by megamolecules. Learn more at the links provided below.  The Emerging Era of Structural...

Milan Discusses Megamolecules with Drug Discovery News

On Feb. 26th 2025, Dr. Milan Mrksich joined the Drug Discovery News webinar entitled Listen In: New drugs on the nanoscale to provide insight into the inspiration, design, and engineering of megamolecules. He demonstrated how megamolecules research can be translated...

Welcome Sichen, Timmy, and Deborah!

The Mrksich Group extends a huge welcome to our newest members from the chemistry department: Timothy Mansfield, Sichen Mu, and Deborah Kovalczuk! Photo: From left to right: Timothy Mansfield, Sichen Mu, Deborah Kovalczuk

About Our Group

Mrksich Group Holiday Party 2023
The Mrksich Group uses the tools of organic chemistry, materials science and biochemistry to address important challenges in and at the intersection of chemistry and biology.
We pioneered the development of MegaMolecules – a new way to engineer protein-based molecules with much greater control over their structure and complexity than with traditional techniques. With this approach, we can build structures composed of more than twenty protein domains, with branched, cyclic and dendritic architectures, and with molecular weights in excess of a million Daltons, for a broad range of basic and applied applications, with an emphasis on biomedical applications such as antibody mimics.
In another program, we emphasize the development of methods to perform high throughput experiments by combining engineered surfaces and mass spectrometry in a technique known as SAMDI-MS. This method has been used extensively to profile enzymatic activity both in situ and in complex lysates while permitting the analysis of tens of thousands of experiments in a day.

Research

Protein Engineering, High-Throughput Experiments, and Surface Chemistry

Megamolecules

Our group developed a platform for assembling large (~MDa), modular, homogeneous protein structures for therapuetic and diagnostic use. 

High-Throughput Experiments

Our group utilizes the inert, ordered structure of self-assembled monolayers with MALDI-MS (SAMDI) to profile biological and chemical reactions in a label-free, high-throughput manner.

Surface Chemistry and Cellular Control

Our group uses microcontact printing, dynamic photoactivation, and other methods to engineer substrates that control cellular adhesion and behavior.

Group Meetings

Group meetings are held in Tech B484. We invite first-year graduate students to attend group meetings to learn more about our lab. Please email mrksich-ofc@northwestern.edu with any questions.

Subgroup Meetings

Subgroup meetings (for lab members and invited guests) are also held in Tech B484

Funding Acknowledgements

Interested in Joining or Have Questions?